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Updated: Oct 7, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

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アシルシランを用いたアルケンのパラジウム触媒サイロキシプロパネーション

Shun Sakurai1, Tetsuya Inagaki1, Takuya Kodama1,2

  • 1Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.

Journal of the American Chemical Society
|January 12, 2022
PubMed
まとめ

アシルシランは,パラジアム触媒によるサイクロプロパネーション反応で,電子が豊富なカルベンを生成する有効な前体である. この突破により シロキシクロプロパンが合成され 複雑なベータ機能化されたケトンが作られます

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Preparation of Alkynes: Alkylation Reaction02:27

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Introduction
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In the first step of the mechanism, the acid protonates the carbonyl oxygen resulting in a resonance-stabilized cation, which subsequently loses an α-hydrogen to form an enol tautomer. The C=C bond in an enol is highly nucleophilic because of the electron-donating nature of the –OH group. Consequently, the double bond attacks an electrophilic halogen to form a...
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