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Updated: Oct 6, 2025

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cGAS-STING経路は,COVID-19におけるIFN型免疫病変を駆動する

Jeremy Di Domizio1, Muhammet F Gulen2, Fanny Saidoune1

  • 1Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.

Nature
|January 19, 2022
PubMed
まとめ

インターフェロン遺伝子 (STING) のサイクルGMP-AMP合成酵素 (cGAS) 刺激経路は,COVID-19における有害な炎症を誘発する. マウスにおけるSTING抑制は肺炎を軽減し,治療結果を改善し,新たな治療目標を示唆した.

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