関連する実験動画

Updated: Oct 6, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

517

LFA-1によるマグネシウム感知は,CD8+ T細胞エフェクター機能を調節する

Jonas Lötscher1, Adrià-Arnau Martí I Líndez2, Nicole Kirchhammer3

  • 1Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland.

Cell
|January 20, 2022
PubMed
まとめ

マグネシウムはT細胞の免疫に不可欠です この研究では,マグネシウムはLFA-1分子にT細胞を活性化させ,病原体や腫瘍と戦う能力を高め,がん治療を改善することを示しています.

キーワード:
CAR T細胞についてMg2+ についてT細胞を誘発する抗体同刺激/LFA-1免疫制御マイクロ環境とT細胞機能の統合マグネシウムメモリ CD8 T細胞マイクロ環境腫瘍特異のT細胞

さらに関連する動画

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

13.2K
Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue06:27

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue

Published on: July 30, 2018

6.7K

関連する概念動画

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
7.6K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.5K
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
5.4K