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Updated: Oct 6, 2025

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

Published on: July 17, 2020

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経路結合とディアゾニウム媒介ヒドラゾン形成によるタシカミドの生物合成

Guang-Lei Ma1, Hartono Candra1, Li Mei Pang1

  • 1School of Biological Sciences, Nanyang Technological University, 637551 Singapore.

Journal of the American Chemical Society
|January 21, 2022
PubMed
まとめ

研究者らは新しい微生物代謝物であるタシカミドを発見し,ユニークなサイクルペプチド基板とヒドラゾン結合を特徴付けました. 生物合成には2つの遺伝子クラスターと 前例のない in vivo Japp-Klingemann 反応が含まれており 自然産物形成の新たな経路を明らかにしています

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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