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Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
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Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

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短距離脊柱二面回転は,内在的に乱れたタンパク質の内部摩擦を調節する

Debapriya Das1,2, Lisha Arora1,2, Samrat Mukhopadhyay1,2,3

  • 1Centre for Protein Science, Design and Engineering, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Sector 81, Mohali, SAS Nagar, Punjab 140306, India.

Journal of the American Chemical Society
|January 24, 2022
PubMed
まとめ

本質的に乱れたタンパク質 (IDP) の内部の摩擦は,溶媒の粘度だけでなく,骨幹二面障壁から生じる. プロリンやグリシンのようなシーケンス固有の残留物は,この摩擦を調節し,タンパク質のダイナミクスに影響を与えます.

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