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Updated: Oct 5, 2025

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

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ヒトの遺伝的および免疫的決定因子 重篤なCOVID-19肺炎

Qian Zhang1,2,3, Paul Bastard4,5,6,7,

  • 1St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. qzhang02@rockefeller.edu.

Nature
|January 28, 2022
PubMed
まとめ

タイプIインターフェロン (IFN) に影響する遺伝的および自己免疫的要因は,少なくとも15%の重篤なCOVID-19肺炎症例を説明します. 呼吸道におけるIFNの不十分な免疫は,年齢や性別によって重症な疾患を引き起こす可能性があります.

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
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