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関連する概念動画

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

51
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
103
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

78
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Prevalence and Incidence01:08

Prevalence and Incidence

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In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
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このページは機械翻訳されています。他のページは英語で表示される場合があります。View in English
  1. ホーム
  3. 研究分野
  5. 生物医学と臨床科学
  7. 心血管医学と血液学
  9. 心臓病 (心血管疾患を含む)
  11. 家族性イディオパシー拡張性心筋病の流行と累積リスク

家族性イディオパシー拡張性心筋病の流行と累積リスク

Gordon S Huggins1, Daniel D Kinnamon2,3, Garrie J Haas3,4

  • 1Cardiology Division, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts.

JAMA
|February 1, 2022

関連する実験動画

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

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PubMed で要約を見る

まとめ
この要約は機械生成です。

家族性拡張性心筋病 (DCM) は一般的であり,黒人患者ではより高い罹患率があります. 親戚の早期スクリーニングは この心臓病の適切な介入に不可欠です

関連する実験動画

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.8K
A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
08:09

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

9.9K
A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

4.9K

科学分野:

  • 心臓病科
  • 遺伝学
  • 公衆衛生

背景:

  • Idiopathic dilated cardiomyopathy (DCM) は家族的な要素があり,予防的な治療を可能にするために親戚の早期発見が必要である.
  • DCMの黒人患者は,白人の患者と比較して不均衡に高い心不全入院と死亡リスクに直面します.

研究 の 目的:

  • DCMと診断された個人 (プロンブ) の間で家族性DCMの有病率を決定する.
  • 異なる人種や民族の親戚で DCM を発症する年齢特有の累積リスクを推定する.

主な方法:

  • 25の米国の心不全センターで1220人のDCMプロバンドと1693人の一級親戚を対象とした家族ベースの横断的な研究です.
  • 家族性DCMは,少なくとも一級親戚にDCMがあることによって定義された.
  • 拡張性DCMは,DCMまたは説明不可能な左心房拡大/静脈機能不全を持つ親族を含む.

主要な成果:

  • 推定DCMの罹患率は29. 7%で,黒人患者では白人患者より高い罹患率 (11. 3%の差異) が認められた.
  • 拡大した家族性DCMの推定罹患率は56. 9%であった.
  • DCMの累積リスクは80歳までに19%に達し,拡張DCMでは33%に達した. DCMの危険性は,非ヒスパニック系黒人プロバンドと非ヒスパニック系白人のプロバンドの親族において有意に高かった (HR,1.89).

結論:

  • 遺伝的DCMはDCM受験者の中で一般的であり,遺伝的評価の重要性を強調しています.
  • 血縁関係者,特に黒人家庭では,DCMおよび関連する心異常を発症する重大な累積リスクがあります.
  • これらの発見は,特に異なる人種や民族の背景を持つ DCM の家族における標的型スクリーニング戦略の必要性を強調しています.