まとめ
ニューロブラストーマで増幅されたN-myc遺伝子は,c-myc.との構造的,機能的な類似性を共有しています. この2つの遺伝子は,類似したイントロン/エクソン組織と同質タンパク質領域を示しており,共通のプロトオンコゲンファミリーであることを示唆しています.
科学分野:
- 腫瘍学 腫瘍学
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
背景:
- N-mycは,ヒトの神経芽細胞腫で増幅され,過剰に発現する細胞遺伝子です.
- N-mycは,変換アッセイにおいてc-mycと同様の変換ポテンシャルを示しています.
- N-mycとc-mycは,潜在的構造的および機能的同質性を持つ関連した原発がん遺伝子である.
研究 の 目的:
- N-mycとc-mycの遺伝子構造と機能の共通とユニークな側面を調査する.
- 人間のN-mycの組織と,そのメッセンジャー製品の核酸配列を決定する.
主な方法:
- 人間のN-myc遺伝子組織の分析.
- N-mycメッセンジャー製品のヌクレオチド配列の決定.
主要な成果:
- N-mycとc-mycは,類似したイントロン/エクソン構造を共有しています.
- N-mycとc-mycのタンパク質製品は,重要なホモロジーの領域を共有しています.
- 類似性にもかかわらず,N-mycとc-mycは,腫瘍と発達において明確な発現パターンを示しています.
結論:
- N-mycとc-mycは,同じプロトオンコゲンファミリーに属しています.
- 構造的および機能的同質性は,それらの関連性を支持する.
- 表現の違いは,特定の生物学的文脈におけるユニークな役割を強調する.
関連する概念動画
The Nucleosome
DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
Histone Variants at the Centromere
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3 variants are also...
Synteny and Evolution
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral chromosome underwent...
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral chromosome underwent...
Multi-species Conserved Sequences
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic cells are...
The Nucleosome
Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...


