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Updated: Oct 4, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.2K

タンパク質設計のための神経ネットワークのバックボーン中心のエネルギー機能

Bin Huang1, Yang Xu1, Xiuhong Hu1

  • 1MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Nature
|February 10, 2022
PubMed
まとめ

SCUBAという新しい統計モデルにより,既存のタンパク質の断片から独立して新しいタンパク質の骨組みを設計することができます. このアプローチは,多様でユニークな de novo タンパク質の作成の可能性を拡大します.

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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