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Updated: Oct 4, 2025

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がんにおけるクラスター化変異のマッピングは,ecDNAのAPOBEC3変異を明らかにする

Erik N Bergstrom1,2,3, Jens Luebeck4,5, Mia Petljak6

  • 1Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.

Nature
|February 10, 2022
PubMed
まとめ

この研究は2,583の癌ゲノムにおけるクラスター化した変異を包括的に分析し,様々な変異過程と癌の誘導因子と患者の生存との関係を明らかにした. APOBEC3は染色体外DNAの進化に 重要な役割を果たしています

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