関連する実験動画

Updated: Oct 3, 2025

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

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肺高血圧における血管細胞機能の新たな調節剤であるSPARC

Christine Veith1, Ipek Vartürk-Özcan1, Magdalena Wujak1,2

  • 1Excellence Cluster Cardio-Pulmonary Institute, University of Giessen and Marburg Lung Center, Member of the German Center for Lung Research (C.V., I.V-Ö., M.W., S.H., C-Y.W., F.K., S.K., A.P., M.G., O.P., M.B., M.H., J.W., F.C.W., K.M., K.S., H.G., K.T., A.Sydykov, A.G., W.S., F.G., H.A.G., R.T.S., N.S., N.W.), Justus-Liebig-University, Giessen, Germany.

Circulation
|February 17, 2022
PubMed
まとめ

システインに富んだ分泌タンパク質 (SPARC) は,肺高血圧 (PH) の発症に重要な役割を果たします. 成人マウスのSPARCをターゲットにすることで,心臓の機能が改善され,PHの治療の可能性が示唆されました.

キーワード:
アポトーシス内皮細胞肺高血圧低酸素筋細胞,滑らかな筋肉

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