コホートから分子へ:内分泌系を乱す混合物の有害な影響
Nicolò Caporale1,2,3, Michelle Leemans4, Lina Birgersson5
1High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy.
Science (New York, N.Y.)
|February 17, 2022
まとめ
妊娠初期に内分泌干渉物質 (EDC) の混合物への曝露は,子供の言語遅延と関連しています. この研究は,EDC混合物に対する新たなリスク評価戦略を策定し,低レベルの曝露で重大な健康上の懸念を明らかにした.
科学分野:
- 環境 健康
- 毒理学について
- 発達生物学
背景:
- 低濃度でも内分泌障害物質 (EDC) は人間の病気と関連しています
- 現行の規制は 単一の化学物質を評価するものです 現実のEDCの混合物ではありません
- EDC混合物へのヒトの曝露は,単一の化学物質の評価で見逃された疾患関連を説明する可能性があります.
研究 の 目的:
- 内分泌系破壊物質 (EDC) の混合物中心のリスク評価戦略を策定し,適用する.
- 産前EDC混合物の暴露と子孫の言語遅延との関連を調査する.
- 人間に適した濃度でのEDC混合物の生物学的効果を評価する.
主な方法:
- 統合された疫学データと実験的証拠
- 実験的な検証のために人間の脳オーガノイド,Xenopus laevisとDanio rerioを使用した.
- ホルモンが制御するネットワークと 行動反応の障害を評価した.
主要な成果:
- EDC混合物への産前暴露は,子孫の言語遅延と関連していました.
- EDCの混合物は,ヒトに関連した濃度で脳オルガノイドとモデル生物の重要な規制ネットワークを混乱させた.
- 子供の54%までには,実験的に得られた懸念レベルを超える産前EDCの暴露が示され,最も高い曝露群では言語遅延のリスクが3. 3倍増加しました.
結論:
- 精密なEDCリスク評価には,混合物中心のアプローチが不可欠です.
- 低濃度で規制された場合でも,EDCの混合物は神経発達に重大なリスクをもたらします.
- 発見は,環境化学物質への併合暴露を考慮する規制戦略の必要性を強調しています.
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