Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Gastrulation01:56

Gastrulation

59.4K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
59.4K
Cleavage and Blastulation01:33

Cleavage and Blastulation

46.3K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
46.3K
Determination01:51

Determination

19.5K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
19.5K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.3K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

3.5K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
3.5K
Lineage Commitment01:21

Lineage Commitment

3.4K
Commitment is the  process whereby stem cells:
3.4K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning.

Cell·2026
Same author

Gaze perception fuels social anxiety in everyday life: a comparison of two ecological momentary assessment models.

BioPsychoSocial medicine·2026
Same author

Long-range mutual activation establishes Rho and Rac polarity during cell migration.

Nature cell biology·2026
Same author

Harnessing the murine inner cell mass mechanical environment enhances derivation of in vitro nascent primitive endoderm precursor cells.

Development (Cambridge, England)·2026
Same author

Xenophagocytosis blockade enhances interspecies chimerism.

Cell·2026
Same author

A conserved antioxidant defense at the endoplasmic reticulum membrane.

Cell reports·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
関連記事をすべて見る

関連する実験動画

Updated: Oct 2, 2025

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
14:08

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

15.4K

細胞表面の変動は,初期の胚の系統分類を制御する

Ayaka Yanagida1, Elena Corujo-Simon2, Christopher K Revell3

  • 1Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK; Centre for Trophoblast Research, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK; Living Systems Institute, University of Exeter, Exeter EX4 4QD, UK.

Cell
|February 23, 2022
PubMed
まとめ
この要約は機械生成です。

静的な性質ではなく 細胞表面のダイナミクスが 胚の組織分離を促します 細胞表面の変動と流動性の差異は,発達中の原始的な内皮と表皮の系統の適切な分離を保証する.

キーワード:
細胞の分類細胞表面の動態細胞表面のメカニズム胚の発達系統分離モルフォゲネシス

さらに関連する動画

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
11:25

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

11.0K
In Vitro Reconstitution of Spatial Cell Contact Patterns with Isolated Caenorhabditis elegans Embryo Blastomeres and Adhesive Polystyrene Beads
07:52

In Vitro Reconstitution of Spatial Cell Contact Patterns with Isolated Caenorhabditis elegans Embryo Blastomeres and Adhesive Polystyrene Beads

Published on: November 26, 2019

7.3K

関連する実験動画

Last Updated: Oct 2, 2025

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
14:08

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

15.4K
Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
11:25

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

11.0K
In Vitro Reconstitution of Spatial Cell Contact Patterns with Isolated Caenorhabditis elegans Embryo Blastomeres and Adhesive Polystyrene Beads
07:52

In Vitro Reconstitution of Spatial Cell Contact Patterns with Isolated Caenorhabditis elegans Embryo Blastomeres and Adhesive Polystyrene Beads

Published on: November 26, 2019

7.3K

科学分野:

  • 発達生物学
  • 細胞メカニズム
  • バイオ物理学

背景:

  • 系統分離は,哺乳類の胚で原始的内皮 (PrE) と表皮質 (EPI) の物理的分離によって示される,胚の発達にとって極めて重要です.
  • 分子因子は知られているが,この空間的分類を制御する物理的メカニズムは不明である.

研究 の 目的:

  • エピブラストと原始的な内皮の系統間の空間的分離の機械的基礎を調査する.
  • 哺乳類の早期発達における細胞分類の基礎となる物理的原理を解明する.

主な方法:

  • 細胞表面の性質を分析するために 先進的な顕微鏡と生体物理学技術を活用した.
  • 細胞分類のダイナミクスをシミュレートし理解するための計算モデルを開発した.
  • 実験データと理論モデリングを組み合わせて,主要な分類メカニズムを特定する.

主要な成果:

  • 静的な機械的差異ではなく 細胞表面の変動が 系統分類に重要であることがわかりました
  • 表面の変動と細胞の流動性との相関性を示し,非均衡の分類メカニズムを提案した.
  • EPIとPrEの空間的分離の主な要因として細胞表面のダイナミクスを特定した.

結論:

  • 細胞表面のダイナミクスは,特に微分的な変動と流動性で,胚の系統の物理的分類を統制する.
  • この非均衡のメカニズムは 異なる細胞タイプが発達中に空間的にどのように組織されるかについての新しい理解を提供します.
  • 組織形成のダイナミックな細胞行動の重要性を強調しています.