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関連する概念動画

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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The Cell Cycle Control System01:28

The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
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Global Regulatory Systems01:28

Global Regulatory Systems

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Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
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Combinatorial Gene Control02:33

Combinatorial Gene Control

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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General Transcription Factors01:30

General Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
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An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

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全局的なタイミングメカニズムは,セルタイプ特有の配線プログラムを規制します.

Saumya Jain1,2, Ying Lin1,3, Yerbol Z Kurmangaliyev2

  • 1Department of Biological Chemistry, University of California, Los Angeles, CA, USA.

Nature
|February 24, 2022
PubMed
まとめ
この要約は機械生成です。

エクディゾンというステロイドホルモンは 転写因子を活性化することで ニューラル回路の組み立てのタイミングを制御します このプロセスは発達中のニューロンの 適切な配線特異性とシナプス接続を保証します

さらに関連する動画

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

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Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
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Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
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科学分野:

  • 神経科学
  • 発達生物学
  • 遺伝学

背景:

  • 神経回路の組み立てには 細胞認識分子の 精密な時空表現が必要です
  • 細胞型特異性因子は知られているが,配線タイミングを決定するメカニズムは未だに難解である.

研究 の 目的:

  • 神経回路形成のタイミングを調節するステロイドホルモンの役割を調査する.
  • ニューロンの配線を制御する分子経路を特定する.

主な方法:

  • ドロソフィラの視覚系ニューロンの単細胞配列解析を用いた.
  • ニューロンの発達と接続性に対する エクディゾンの経路障害の影響を分析した.
  • 転写因子と配線遺伝子の間の規制関係を調査した.

主要な成果:

  • エクディゾンは,視覚系の神経細胞全体で転写因子カスケードを誘導し,シナプス成熟と配線特異性を調節する.
  • 細胞表面のタンパク質を含む,エクディゾン経路の共通および細胞型特異の標的を特定した.
  • 転写因子発現の順序が連続的な配線イベントと相関し,その中断が特定の発達障害を引き起こすことを実証した.

結論:

  • ニューロンは,正確な配線を達成するために,細胞タイプ特異的な因子とグローバルタイムトランスクリプションモジュール (ecdysone経路) を統合します.
  • この統合システムは 精密な神経回路形成に不可欠な 細胞型特異的な細胞認識分子のパターンを生成します