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Updated: Oct 2, 2025

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低用量メトホルミンは,PEN2経由でリンソームのAMPK経路を標的とする

Teng Ma1, Xiao Tian1, Baoding Zhang1

  • 1State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.

Nature
|February 24, 2022
PubMed
まとめ

一般的な糖尿病薬であるメトホルミンは,リゾソームに関与するタンパク質PEN2に直接結合します. この相互作用はAMP活性化タンパク質キナーゼ (AMPK) を活性化させ,メトホルミンの抗老化および抗癌効果を説明します.

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