関連する実験動画

Updated: Oct 2, 2025

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

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高興奮性の覚醒回路は老化中に睡眠の不安定性を引き起こす

Shi-Bin Li1,2, Valentina Martinez Damonte1,2, Chong Chen3,4

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|February 24, 2022
PubMed
まとめ

高興奮性ハイポクレチン/オレキシン (Hcrt/OX) ニューロンにより,老化により睡眠の質が低下する. Hcrtニューロンの低KCNQ2発現は睡眠の断片化を引き起こしますが,KCNQ活性化剤は老いたマウスの睡眠継続を回復することができます.

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