柔軟で文脈依存のセンソモーター配列の皮質処理
Duo Xu1, Mingyuan Dong1, Yuxi Chen2
1The Solomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Brain Science Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nature
|March 10, 2022
まとめ
研究者達は のタスクを使って 運動シーケンスに対する脳の制御を研究しました 主要な体感皮質 (S1TJ) と運動皮質 (M1TJ) のような 特定の脳の領域が 舌の動きを制御し 運動前皮質は 配列計画を管理します
科学分野:
- 神経科学
- モーター コントロール
- 計算神経科学
背景:
- 柔軟で文脈に依存する 動きのシーケンスを生成する脳の能力は 行動に不可欠です
- 連続的な運動生成の背後にある神経メカニズムの理解は,特にリアルタイムでの調整は,依然として課題です.
研究 の 目的:
- 哺乳類の脳における 柔軟で文脈に基づいた 連続的な運動生成の 神経的基礎を調査する.
- 複雑な運動配列の制御とエンコーディングにおける 異なる皮質領域の役割を解明する.
主な方法:
- ネズミが動く標的を舌で操作する"シーケンス・ライキング"の開発.
- 閉じたループの光遺伝学と 電気生理学を使って 神経活動を記録し操作した
- 運動パラメータと潜在的行動変数のニューラルエンコーディングの分析.
主要な成果:
- 主要な体感皮質 (S1TJ) と運動皮質 (M1TJ) は,個々の舌運動を正確にコードし,制御する.
- 前側運動皮質 (舌前運動皮質) は,意図された角やシーケンス進行などの抽象的な変数をコードします.
- 前側運動皮質とM1TJの両方で運動非特異的な分岐信号が観察されました.
結論:
- 特定の皮質領域は 柔軟な運動シーケンスを生成する上で 特殊な役割を果たします
- S1TJとM1TJは繊細な舌の動きの実行に不可欠です.
- 前側運動皮質は,より高いレベルの計画と,動きのシーケンスの文脈的調節に寄与する.
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