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Updated: Sep 30, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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Published on: November 2, 2018

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ジャヌスキナーゼ・サイトカイン受容体の構造は,二次活性化の基礎を明らかにする

Caleb R Glassman1, Naotaka Tsutsumi1,2, Robert A Saxton1,2

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|March 10, 2022
PubMed
まとめ

ジャヌスキナーゼ1 (JAK1) の冷凍電子顕微鏡構造を,サイトカイン受容体との複合で決定した. この構造は,JAK1の変異が新しい治療標的を提示し,構成的活性化を促すことで癌を駆動する方法を明らかにします.

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