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Updated: Sep 30, 2025

Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
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Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique

Published on: January 14, 2016

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ヒストンH3.1変種は,複製中のTONSOKU媒介DNA修復を調節する

Hossein Davarinejad1, Yi-Chun Huang2, Benoit Mermaz2

  • 1Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

Science (New York, N.Y.)
|March 17, 2022
PubMed
まとめ

ヒストンH3.1は,アラニン31経由でTONSOKU (TSK) と相互作用し,複製にユニークな役割を果たしています. この相互作用は,特にヒストンH3ライシン27単甲基化が欠けるとき,ゲノムの安定性にとって極めて重要です.

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