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Updated: May 5, 2026

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TFPIは,ハイパーウイルス性クラード2C. difficileからのTcdBの結腸暗号受容体である

Jianhua Luo1, Qi Yang1, Xiaofeng Zhang2

  • 1Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310024, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.

Cell
|March 18, 2022
PubMed
まとめ

超毒性のClostridioides difficile菌株は,受容体として組織因子経路阻害剤 (TFPI) を使用する. この発見は,TFPIがTcdBの結腸暗号受容体であることを明らかにし,C. difficile感染の病原性に関する新しい洞察を提供します.

キーワード:
CDIの病原性CRISPR/Cas9スクリーンクロストリディオイドス・ディフィシアルTcdBクラード2 C. difficile大腸の密室クリオ・エム構造レセプター組織因子経路阻害剤

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