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T細胞におけるアンドロゲン受容体の活性が,チェックポイント阻害の有効性を制限する

Xiangnan Guan1,2,3, Fanny Polesso4, Chaojie Wang4,5

  • 1Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.

Nature
|March 24, 2022
PubMed
まとめ

アンドロゲン受容体 (AR) 阻害はCD8T細胞の機能を高め,前立腺がんにおける免疫療法反応を改善する. このアプローチはT細胞の枯渇を防止し,IFNγの発現を刺激することで抗腫瘍免疫を高めます.

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