妊娠中のSARS-CoV-2ワクチン接種と妊娠の結果の関連
Maria C Magnus1, Anne K Örtqvist2,3, Elisabeth Dahlqwist2
1Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
JAMA
|March 24, 2022
まとめ
妊娠中のCOVID-19ワクチン接種は,早産や死産などの有害な結果のリスクを増加させなかった. この研究には15万7千人以上の妊婦が含まれており,ほとんどの予防接種は第2期と第3期で行われました.
科学分野:
- 産婦人科
- ワクチン学
- 公衆衛生
背景:
- 妊娠中のSARS-CoV-2に対するワクチンの安全性に関するデータは限られている.
- 妊婦のCOVID-19ワクチン接種後の妊娠結果を評価することは,公衆衛生上の勧告にとって極めて重要です.
研究 の 目的:
- 妊娠中のSARS-CoV-2ワクチン接種と妊娠中の有害な結果との関連を調べる.
- 新生児の早産,死産,その他の合併症のリスクを評価する.
主な方法:
- スウェーデンとノルウェーのレジストリデータを用いた遡及的なコホート研究.
- mRNAとウイルスベクトルワクチンの暴露に関するデータを分析した単体妊娠157,521件を含む.
- 統計モデル (コックス回帰,ロジスティック回帰) とメタ解析を用いてリスクを評価した.
主要な成果:
- 妊娠中のSARS-CoV-2ワクチン接種と早産,死産,妊娠年齢に比べて小さい,Apgarスコアが低い,または新生児の入院のリスクの増加との間に有意な関連性は見つかりませんでした.
- すべての評価結果の調整された危険比率と確率比率は1に近いもので,信頼区間は1を含む.
- ほとんどの予防接種は,主にmRNAワクチンで,第2期と第3期に発生しました.
結論:
- 妊娠中のSARS-CoV-2ワクチン接種は,ワクチン接種なしと比較して,この大規模な集団ベースの研究で妊娠の悪影響と関連付けられませんでした.
- 調査結果から,COVID-19 ワクチン接種は,妊娠中の大きな有害事象に関して,妊娠中の個人に安全であることを示唆しています.
- この研究は,妊娠後期に投与されるmRNAワクチンの安全性を強調しています.
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