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Updated: Sep 29, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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サイクルダイヌクレオチドMK-1454のステレオ選択合成のための様々な触媒反応

Tamas Benkovics1, Feng Peng1, Eric M Phillips1

  • 1Department of Process Research and Development, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States.

Journal of the American Chemical Society
|March 25, 2022
PubMed
まとめ

この研究は,MK-1454というSTING経路アゴニストを酵素催化カスケードを用いて高度にダイアステロ選択的に合成したものである. この革新的なアプローチは新しい結合形成戦略と 効率的で選択的な構築のための酵素処理を組み合わせています

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