関連する実験動画

Updated: Sep 28, 2025

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
04:41

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

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LGR5 を発現する皮膚線維芽細胞は,硬化症で混乱する主要な細胞ハブを定義する

Chamutal Gur1, Shuang-Yin Wang2, Fadi Sheban2

  • 1Department of Systems Immunology, Weizmann Institute, Rehovot, Israel; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.

Cell
|April 5, 2022
PubMed
まとめ

組織性硬化症 (SSc) は,特に新型硬化症関連フィブロブラスト (ScAF) の免疫およびストロマ細胞機能不全を伴う. この研究は,SScバイオマーカーと治療法の分子標的を明らかにしています.

キーワード:
FOS についてGVHD についてLGR5 についてTWIST1 について自己免疫性フィブロブラスト繊維症皮膚について組織性硬化症

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Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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