人間の寿命に関する脳図

R A I Bethlehem^1,2, J Seidlitz^3,4,5, S R White^6,7

¹Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. rb643@medschl.cam.ac.uk.

Nature

|April 7, 2022

まとめ

脳図は10万人以上のMRIデータを用いて脳形状の基準を示しています脳の発達と寿命の間の個々の違いを定量化することができます

科学分野:

神経イメージング
発達神経科学
バイオ統計学

背景:

神経イメージングは脳研究で広く使用されていますが,時間の経過とともに個々の脳メトリックの標準化された参照チャートは欠けています.
既存の人体成長図は身体的発達の基準を示し神経科学における同様のツールの必要性を強調しています

研究の目的:

MRIデータから脳形状をベンチマークするためのインタラクティブでオープンなリソース (brainchart.io) を作成する.
脳の構造を定量化するための基準を確立する

主な方法:

100以上の研究で,101,457人の被験者 (胎児から100歳まで) の123,984件のMRIスキャンを集めた.
脳の構造の変化の寿命経路に相対的なセンチルスコアを用いた数値化されたMRI測定値
評価された安定性,技術的変化に対する強度,センチルスコアの遺伝性.

主要な成果:

神経発達における新たなマイルストーンを特定し, 時間の経過とともに脳構造の高い個別の安定性を示した.
脳の図は,研究間の方法論的差異に対する強度を示した.
センチルスコアは遺伝性の増加を明らかにし,障害における神経解剖学的変化の標準的な尺度を提供した.

結論:

脳図は,標準的な経路に対して神経イメージングのフェノタイプにおける個々の変化を堅く定量化するための重要なツールを提供します.
このリソースは,発達と臨床集団における脳の構造の標準化比較を容易にする.

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