ミネラライゼーションは,コラーゲン繊維にメガパスカルの収縮ストレスを生成する
Hang Ping1,2, Wolfgang Wagermaier2, Nils Horbelt2
1State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Luoshi Road No. 122, Wuhan 430070, China.
まとめ
コラーゲン線維内の鉱化により 収縮し,大きなストレスが生じます この繊維内鉱化により 骨の形成を模倣した 強く強化された複合材料が生成されます
科学分野:
- バイオマテリアル科学
- バイオミネラル化
- 材料科学
背景:
- 骨は炭酸ヒドロキシアパタイトで鉱化されたコラーゲン繊維で構成されるハイブリッド材料です.
- コラーゲンのミネラルの核化能力は,in vitroで知られている.
- 繊維内鉱化を理解することは,生物模倣材料設計の鍵です.
研究 の 目的:
- コラーゲン繊維内の鉱物沈殿の化学的効果を調査する.
- イントラフィブリル鉱化中に発生したストレスを定量化するために.
- 鉱物の堆積の運動とコラーゲン構造への影響を分析する
主な方法:
- コラーゲン繊維内のストロンチウムとカルシウムベースの鉱物の降水.
- 鉱物堆積の運動を分析するシンクロトロンX線散射.
- ミネラル・コラーゲン複合材料による機械的ストレスの測定
主要な成果:
- コラーゲン繊維内の鉱物沈殿は,重要な繊維収縮を誘導し,数メガパスカルのストレスを発生させます.
- 収縮のストレスの大きさは,形成された鉱物の種類と量に依存します.
- 線維内鉱化が原因で線維外収縮は起こらない.
- この過程は コラーゲンが完全に水に浸った状態でも起こります
結論:
- コラーゲン組織内の機械的ストレスを生成する強力なメカニズムである.
- このプロセスは,鉄筋コンクリートに類似した,張力繊維で強化された複合材料を生成します.
- この発見は骨の形成や 新しいバイオミメティック材料の開発の 洞察力を与えてくれます
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