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Updated: Sep 27, 2025

LERLIC-MS/MS for In-depth Characterization and Quantification of Glutamine and Asparagine Deamidation in Shotgun Proteomics
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デュアルタンパク質触媒によるアミノ酸の部位選択的脱塩

Tyler J Doyon1, Andrew R Buller1

  • 1Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

Journal of the American Chemical Society
|April 13, 2022
PubMed
まとめ

アミノ酸の酵素によるデュテリウムラベル付けは,選択的なCαとCβ水素-デュテリウム (H/D) 交換を可能にする2タンパク質システムによって強化されます. この方法は,デュテラートアミノ酸合成のサイト選択性を改善します.

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