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Updated: Sep 27, 2025

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
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Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions

Published on: August 30, 2024

879

テロメアシェルテリンタンパク質 TPP1 の活性ヒトテロメラーゼの構造

Baocheng Liu1, Yao He1,2, Yaqiang Wang1

  • 1Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.

Nature
|April 14, 2022
PubMed
まとめ

ヒトのテロメラーゼ (TERT) とテロメラーゼRNA (TER) の構造は,シェルテリンタンパク質TPP1がテロメラーゼを募集し活性化する方法を示しています. これらの発見はテロメラーゼ機能とテロメロパシーの潜在的な薬物の標的を明らかにします.

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