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Updated: Sep 27, 2025

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
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粘着GPCRsADGRD1とADGRF1の結合アゴニズムの構造的基礎

Xiangli Qu1,2, Na Qiu1,2, Mu Wang1,3

  • 1CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Nature
|April 14, 2022
PubMed
まとめ

粘着Gタンパク質結合受容体 (aGPCRs) は,割れではなく,結合した茎領域で活性化します. 構造的研究は,保存された茎-トランスメブラン相互作用とADGRF1の脂質結合部位を明らかにし,aGPCRのシグナリングの複雑さを明らかにした.

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