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Updated: Jul 21, 2026

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms
13:40

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms

Published on: July 7, 2011

C端末信号は,光のERタンパク質の分泌を防ぐ

S Munro, H R Pelham

    Cell
    |March 13, 1987
    PubMed
    まとめ

    エンドプラズマ網膜 (ER) は,特定のC端末信号を用いてタンパク質を保持する. Lys-Asp-Glu-Leu (KDEL) 配列は,ERの光タンパク質を誘導し,その分泌を防止する.

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    関連する概念動画

    Role of ER in the Secretory Pathway01:17

    Role of ER in the Secretory Pathway

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    Directing Proteins to the Rough Endoplasmic Reticulum

    The organelle-specific signaling sequences direct proteins synthesized in the cytosol to their final destination like ER, mitochondria, peroxisomes, etc. Some of the proteins directed to ER are then trafficked via vesicles to other organelles within the cell or the extracellular environment through the Golgi complex. For example, the rough ER synthesizes soluble proteins for transportation to the lysosomes or secretion out of the cell. It can also synthesize transmembrane proteins that can...
    Cotranslational Protein Translocation01:20

    Cotranslational Protein Translocation

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    Insertion of Single-pass Transmembrane Proteins in the RER

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    Tail-anchoring of Proteins in the ER Membrane01:45

    Tail-anchoring of Proteins in the ER Membrane

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    GPI Anchoring of Proteins in the ER Membrane01:29

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