関連する実験動画

Updated: Sep 25, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

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細胞質染色体の破裂 病理的なDNA塩基切除修復

Shangming Tang1,2,3, Ema Stokasimov1,2,3, Yuxiang Cui4

  • 1Howard Hughes Medical Institute, Chevy Chase, MD, USA.

Nature
|April 27, 2022
PubMed
まとめ

癌や病気の原因であるクロモトリプシスには,マイクロ核のRNA-DNAハイブリッドによるDNA損傷が含まれています. ADAR酵素はデオキシニノシンを作り,MPGとAPE1がそれを分解して染色体を分割する.

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