神経免疫性心血管界面が動脈硬化症を制御する
Sarajo K Mohanta1,2, Li Peng3, Yuanfang Li4
1Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany. Sarajo.Mohanta@med.uni-muenchen.de.
Nature
|April 28, 2022
まとめ
周周神経系は,病気の動脈で神経免疫性心血管界面 (NICI) を形成し,動脈-脳回路 (ABC) を形成し,動脈硬化に影響します. このABCをターゲットにすることで 疾患の進行を遅らせ,プラークの安定性を改善することができます.
科学分野:
- 心血管生物学
- 神経免疫学
- 血管生物学
背景:
- 動脈硬化には動脈のプラークが含まれるが,神経制御に関する明確な理解がない.
- アドベンチアの免疫反応は 病気の動脈との 神経相互作用の可能性を示唆しています
研究 の 目的:
- 周辺神経系と動脈硬化症の相互作用を調査する.
- 病気の動脈における神経免疫性心血管界面 (NICI) を特定し,特徴づけること.
主な方法:
- ネズミと人間の動脈硬化性動脈の断片をNICIのために分析する.
- 神経解剖学的および機能的測定を用いた動脈-脳回路 (ABC) の追跡.
- 動脈硬化症の進行とプラークの安定性を評価する.
主要な成果:
- 拡張した軸索ネットワークを持つ広範囲にわたるNICIは,動脈硬化性アドベンチアで発見されました.
- 動脈と中枢神経系をつなぐアフェラントとエフェラントニューロンを含む構造的ABCが確立された.
- 病変の進行と相関するABC成分の活性化; ガンジレオクトミーは病変を軽減し,プラークを安定させました.
結論:
- 周辺神経系はNICIを形成し,動脈硬化症を調節するABCを作ります
- ABCの治療標的は,動脈硬化症を緩和し,プラークの安定性を高める可能性を示しています.
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