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がん細胞は,遺伝子毒性ストレスによって課される成長制限を回避するために,自己発生したDNAの破裂を利用する

Brian D Larsen1, Jan Benada1, Philip Yuk Kwong Yung2

  • 1Biotech Research and Innovation Centre, University of Copenhagen, 2200 N Copenhagen, Denmark.

Science (New York, N.Y.)
|April 28, 2022
PubMed
まとめ

ガン細胞は,カスパース活性化DNase (CAD) によって制御される,一時的なDNA断裂を生成することで,放射線治療を生き延びます. これは早めの細胞分裂を防ぎますが CADを無効にすると 腫瘍はDNA損傷に脆弱になります

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