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Updated: May 7, 2026

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
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Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

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哺乳類の組織における細胞用薬標的のインサイト識別

Zhengyuan Pang1, Michael A Schafroth2, Daisuke Ogasawara2

  • 1Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.

Cell
|April 28, 2022
PubMed
まとめ

研究者は,クリアリングアシスト組織クリック化学 (CATCH) を開発し,無傷の組織で薬物の標的を視覚化しました. この方法は薬物の分布と細胞の種類をサブセルラー解像度で明らかにし, in vivo 薬物の作用の研究を進めています.

キーワード:
クリック 化学コヴァレント阻害剤麻薬の配布ドラッグターゲットの関与分子イメージングターゲット識別

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