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Updated: Sep 25, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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感染したマクロファージの炎症体活性化がCOVID-19の病理を誘発する

Esen Sefik1, Rihao Qu1,2,3, Caroline Junqueira4,5,6

  • 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Nature
|April 28, 2022
PubMed
まとめ

重度のCOVID-19は,SARS-CoV-2に感染したマクロファージによって引き起こされる肺炎を伴う. インフラマソームを活性化すると 細胞死亡が起こり ウイルスの拡散が制限され 炎症が増加します この経路を遮断すると 肺の損傷は逆転しますが 感染症ウイルスは放出されます

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