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関連する概念動画

DNA as a Genetic Template02:05

DNA as a Genetic Template

22.9K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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DNA Packaging00:58

DNA Packaging

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Overview
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Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
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The DNA Helix01:07

The DNA Helix

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Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
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Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

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Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Updated: Sep 24, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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ゲオメトリによるDNA 自己組み立てプログラム†

Cuizheng Zhang1, Mengxi Zheng1, Yoel P Ohayon2

  • 1Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Journal of the American Chemical Society
|May 4, 2022
PubMed
まとめ
この要約は機械生成です。

この研究は DNA 自己組み立てのための幾何学的なプログラミングを導入し,配列ベースの方法を補完します. DNAモチーフの枝の長さを調整することで,混合,分類,並び替えなどの結晶形成を正確に制御できます.

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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

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関連する実験動画

Last Updated: Sep 24, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

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Designing a Bio-responsive Robot from DNA Origami
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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
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科学分野:

  • 生物化学
  • 材料科学
  • ナノテクノロジー

背景:

  • ナノスケール構造を作る 強力な技術です
  • 現在の方法は,主にアセンブリプログラミングのシーケンス互補性に依存しています.
  • 精密なDNAモチーフの配置には 幾何学的な制約が重要な役割を果たします

研究 の 目的:

  • タイルベースのDNA自己組み立てのための新しい幾何学的なプログラミング戦略を導入し,実証する.
  • 配列を中心とした既存のDNAアセンブリ方法を補完する.
  • 2Dと3DのDNA自己組み立ての プログラミングの多様性を拡大します

主な方法:

  • DNAモチーフの幾何学的な特性を利用し,特に枝の長さと螺旋状の回転相.
  • DNAモチーフのデザインは同じですが 幾何学的なパラメータは違います
  • これらの幾何学的に異なるモチーフの自己組み立て行動を調査します.

主要な成果:

  • 均質なDNA結晶のプログラムが証明された
  • 混合モチーフのDNA "合金"結晶の自己組み立てを達成しました.
  • 幾何学的な制御で 定義可能な粒子の境界を プログラムした.
  • 枝の長さを調整することで,モチーフの混合,自己分類,並べ替えを制御することが示されました.

結論:

  • ゲオメトリック・プログラミングは DNAの自己組み立てを 制御する新しい次元を提供します
  • ジオメトリックとシーケンスベースの戦略を統合することで,プログラミング能力が大幅に向上します.
  • このアプローチにより 複雑で精密な構造の DNA 材料が作られます