リンパ節の植民地化は,遠隔転移を促進する腫瘍免疫耐性を誘発する

Nathan E Reticker-Flynn¹, Weiruo Zhang², Julia A Belk¹

¹Department of Pathology, Stanford University, Stanford, CA 94305, USA.

Cell

|May 7, 2022

まとめ

固体腫瘍におけるリンパ節転移は,遠隔に広がるのを積極的に促進する. リンパ節の腫瘍は免疫反応を回避し,耐性を誘発し,さらなるコロニー化と全身疾患の進行を促進します.

科学分野:

腫瘍学
免疫学
癌の転移

背景:

リンパ節 (LN) の関与は,遠隔転移の可能性を示す固体悪性腫瘍の重要な予後要因です.
遠隔転移の形成におけるLN転移の有効な役割は,まだ十分に理解されていません.

研究の目的:

LNに広がる腫瘍のメカニズムを調査する
遠くの組織への転移に LN 植民が影響するかどうかを判断する.

主な方法:

LN転移のシンジェニックメラノーママウスモデルの開発.
腫瘍内部のインターフェロン反応プログラムの分析
LN内の免疫回避とコロニー化ダイナミクスの評価

主要な成果:

エピジェネティックに制御された腫瘍内部のインターフェロン反応は,LNの転移の可能性を高めます.
この反応は自然殺虫剤 (NK) 細胞の脱出を促進し,LNの植民を促します.
LN転移は,T細胞媒介による殺戮に抵抗し,調節性T細胞を誘導し,免疫耐性を確立し,遠隔コロニー化を促進する.

結論:

LN転移は,免疫回避と耐性誘導によって,遠隔の拡散を積極的に促進する.
このメカニズムは異なる癌の種類や種にわたって保たれています
このプロセスの理解は転移性疾患の管理のための潜在的な治療目標を提供します.

キーワード:

ISG について MHC-I NK細胞 PD-L1 についてトレグスインターフェロンリンパ節転移する規制T細胞トレランス

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