地中海食と低脂肪食による心臓血管疾患の長期的な二次予防 (CORDIOPREV):ランダム化制御試験
Javier Delgado-Lista1, Juan F Alcala-Diaz1, Jose D Torres-Peña2
1Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, Córdoba, Spain; Department of Medical and Surgical Sciences, Universidad de Córdoba, Córdoba, Spain; Maimonides Institute for Biomedical Research in Córdoba (IMIBIC), Córdoba, Spain; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
Lancet (London, England)
|May 7, 2022
まとめ
地中海ダイエットは,既定の冠動脈疾患の患者に,低脂肪ダイエットと比較して,重大な心血管疾患を著しく減少させた. この研究は,二次性心血管疾患の予防のための地中海ダイエットを支持しています.
科学分野:
- 心臓病科
- 栄養学
- 予防 医療
背景:
- 心血管疾患 (CVD) の予防は公衆衛生上の大きな関心事である.
- 地中海食と低脂肪食の両方が,一次性CVD予防に有効であることが示されています.
- 二次予防の設定におけるこれらのダイエットの比較効果は,さらなる調査を必要とした.
研究 の 目的:
- 地中海食と低脂肪食の長期的な効果を比較して 心血管疾患の二次予防を図る.
- 主要な心血管疾患に対するこれらの食事介入の影響を評価する.
主な方法:
- 既定冠動脈疾患の患者1002人を対象とした7年間のランダム化臨床試験 (CORDIOPREV研究)
- 参加者は地中海食または低脂肪食の介入に割り当てられました.
- 主なアウトカムは,治療意図分析によって評価された主要な心血管疾患の複合体でした.
主要な成果:
- 地中海ダイエットグループは,低脂肪ダイエットグループ (111人) と比較して,重症心血管疾患 (87人) が少なかった.
- 主要エンドポイントの危険比率は地中海食 (HR 0. 719- 0. 753) を好みました.
- これらの効果は男性においてより顕著であり,地中海食群では心血管疾患の有意な減少が観察された.
結論:
- メジャーな心血管疾患の二次予防には,低脂肪食より地中海食の方が優れている.
- 臨床では,既存の冠動脈疾患の患者に地中海ダイエットを推奨することを検討する必要があります.
- 食事の介入は二次的な予防において 心血管疾患のリスクを管理する上で重要な役割を果たします
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