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Updated: Sep 23, 2025

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
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自動抑制回路を妨害すると,脱出抵抗性の抗ウイルス剤を生成する"オープンループの致死性"が生成されます

Sonali Chaturvedi1, Michael Pablo1, Marie Wolf1

  • 1Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA.

Cell
|May 13, 2022
PubMed
まとめ

核酸の誘導体で遺伝子ネットワークの負のフィードバックを妨害すると ウイルスの"オープン・ループの致死性"が生じ,複製を阻害する. この新しい抗菌戦略は,ヘルペスウイルスやSARS-CoV-2などのウイルスに対する高い耐性障害を示しています.

キーワード:
自動制御回路フィードバック核酸合成生物学転写フィードバックウイルスの進化

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