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Updated: Sep 23, 2025

Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling
08:51

Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling

Published on: June 25, 2015

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保存された細菌の毒性因子の一族は,カルシウムシグナル伝達を阻害することによって,インターフェロン反応を抑制する

Noémie Alphonse1, Joseph J Wanford2, Andrew A Voak2

  • 1Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK; Immunoregulation Laboratory, Francis Crick Institute, London, UK.

Cell
|May 14, 2022
PubMed
まとめ

シゲラ菌は重要なカルシウムセンサーであるカルモジュリンを標的にして,インターフェロン (IFN) 信号伝達を阻害します. OspCタンパク質を含むこのメカニズムは,免疫反応を阻害し,他の病原体でも保存されます.

キーワード:
カイ ((2+)カムキイISG についてJAK/STAT についてオスプC1オスプC3シゲラT3SS についてカルシウムカルモジュリン宿主と病原体の相互作用インターフェロン

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