Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

RNA Interference01:23

RNA Interference

26.5K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
26.5K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

17.0K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
17.0K
Experimental RNAi02:15

Experimental RNAi

6.3K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.3K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
Types of RNA01:23

Types of RNA

67.5K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
67.5K
RNA Structure01:23

RNA Structure

73.5K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
73.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Molecular and clinical characterization of respiratory syncytial virus genotypes in a medical centre in Central Taiwan across the COVID-19 era.

Journal of infection and public health·2026
Same author

A hybrid radiomics framework integrating genetic algorithm-optimized random forest for preoperative identification of Luminal B breast cancer and Ki-67 prediction: A multicenter study.

The ultrasound journal·2026
Same author

Elucidating structure-function relationships in the mammalian nucleolus.

Nature reviews. Molecular cell biology·2026
Same author

DockingDB: An online reverse-docking database for plant hormone research.

Plant communications·2026
Same author

Clinical value of the adjustable suspension technique in laparoscopic pyeloplasty.

Frontiers in surgery·2026
Same author

Arbuscular Mycorrhizal Fungi May Account for a Phosphorus-Facilitation Strategy.

Plant, cell & environment·2026

関連する実験動画

Updated: Sep 22, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.7K

円形RNA:特徴,細胞の役割,および用途

Chu-Xiao Liu1, Ling-Ling Chen2

  • 1State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.

Cell
|May 18, 2022
PubMed
まとめ

円形RNA (circRNAs) は,遺伝子発現を調節する多機能分子である. この進歩により,細胞プロセスにおける circRNA の役割と,潜在的な生物医学的な応用が研究できるようになった.

キーワード:
RBP についてRNAサークルRNA結合タンパク質アプタマーバックスプライシングcircRNA について循環型RNAの適用円形RNAモード循環型RNA療法円形のRNA翻訳免疫性について

さらに関連する動画

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.4K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.4K

関連する実験動画

Last Updated: Sep 22, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.7K
Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.4K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.4K

科学分野:

  • 分子生物学
  • 遺伝学
  • 生物化学

背景:

  • 円形RNA (circRNAs) は,前体mRNAのバックスプライシングから発生する.
  • 技術的進歩は,circRNAの構成と機能を研究するのに役立ちます.
  • サークルRNAは細胞の調節に様々な役割を果たします.

研究 の 目的:

  • サークRNAを研究する方法を検討する.
  • サークRNAの調節機能に関する現在の知識を要約する.
  • サークRNAの新たな応用を探求する.

主な方法:

  • サークRNA研究における現在の文献と技術的進歩のレビュー.
  • DNA,RNA,タンパク質とのcircRNA相互作用の分析
  • 転写,スプライシング,翻訳におけるcircRNAの役割の検討.

主要な成果:

  • サークRNAは様々なメカニズムで遺伝子発現を調節する.
  • 局所化と相互作用が circRNA機能を決定する.
  • サークRNAは治療や研究に活用できる可能性がある.

結論:

  • circRNAは重要な生物学的影響を持つ重要なレギュレータである.
  • circRNAのメカニズムと応用に関するさらなる研究が必要である.
  • circRNAは 生物医学的な介入に 新たな道を開きます