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関連する概念動画

Blood Flow01:29

Blood Flow

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Structure of Blood Vessels01:15

Structure of Blood Vessels

Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Anatomy of Blood Vessels01:20

Anatomy of Blood Vessels

The vascular system, an integral part of the circulatory system, comprises various blood vessels that play crucial roles in maintaining the body's homeostasis. These blood vessels form a complex and efficient circulatory network. The three primary categories of blood vessels are the arteries, veins, and capillaries.
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta, have...

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Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
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構造的にプログラムされた毛細血管の流れのマイクロ流体連鎖反応

Mohamed Yafia1,2, Oriol Ymbern1,2, Ayokunle O Olanrewaju1,2,3

  • 1Biomedical Engineering Department, McGill University, Montreal, Quebec, Canada.

Nature
|May 18, 2022
PubMed
まとめ

マイクロフリウイド連鎖反応 (MCR) を開発しました プログラム可能な自己制御液体処理を チップ上で行います この技術革新により 外部機器を必要とせずに 複雑な検査と診断が可能になり 汎用的なラボ・オン・ア・チップの 応用が可能になりました

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Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
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18:11

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科学分野:

  • バイオテクノロジー
  • マイクロ流体
  • 化学工学

背景:

  • 鎖反応は化学的および生物学的プロセスに不可欠ですが,マクロスコーピーの応用は限られています.
  • マイクロフリウジック・ラボ・オン・ア・チップ・システムは,しばしば自動化のために外部周辺機器に依存する.
  • 既存の毛細血管微流体には 複雑な液体処理のための高度なプログラム性が欠けている.

研究 の 目的:

  • マイクロ流体連鎖反応 (MCR) を導入し,自律的でプログラム可能な毛細血管の流れを制御する.
  • シングル・チップで 複雑な液体処理アルゴリズムの 能力を実証する
  • MCRの潜在能力を示し, オン・チップ装置をプログラムする.

主な方法:

  • MCRを統合した単体チップの3Dプリント
  • 紙ポンプで生成された自由エネルギーを自律的に使用します.
  • 毛細血管の流れの条件付き,構造的にプログラムされた伝播のためのMCRの開発.

主要な成果:

  • 相互接続されたチップの間で 300 アリクォートの自動連鎖リリース.
  • SARS-CoV-2 抗体検出プロトコルの成功実装.
  • 連続したサブサンプリングと並行した操作によるトロンビン生成測定が実証された.

結論:

  • MCR技術は,無制限で自律的な液体処理を提供します.
  • MCRはプログラム構造を in situでコードし,省エネで汎用的なlab-on-a-chipデバイスを可能にします.
  • このアプローチは,液体処理と診療所の診断において幅広い応用があります.