感覚皮質のコード化と領域間通信における新興の信頼性
Sadegh Ebrahimi1,2,3,4, Jérôme Lecoq5,6,7,8, Oleg Rumyantsev5,6,9
1James Clark Center for Biomedical Engineering, Stanford University, Stanford, CA, USA. sadegh@stanford.edu.
Nature
|May 19, 2022
まとめ
ニューラル通信を動的に再構成することで 感覚的差別を高めます これは情報共有の一時的な増加と 信頼性の高い知覚のために個々のニューロン変動を克服する 堅固な集団コードを伴う.
科学分野:
- 神経科学
- システム神経科学
- 計算神経科学
背景:
- 信頼性の高い感覚的識別には 高精度な神経表現と 領域間のコミュニケーションが必要です
- 神経皮質の感覚処理が神経応答の変動性を克服するメカニズムは完全に理解されていません.
研究 の 目的:
- 神経皮質がどのように神経活動とコミュニケーションを 動的に管理するかを研究する.
- 視覚的なタスク中に 神経イベントと機能的な接続性の変化の時間的なシーケンスを解明する.
主な方法:
- ネズミの新皮質の8つの領域で5日間にわたる神経活動の長距離インビボ画像.
- 21,000以上のニューロンを同時に記録する 視覚的識別タスク
- アクティビティコフラクチュエーションと脳領域間の情報伝達による機能的接続性の分析
主要な成果:
- 新皮質の機能的接続は刺激開始から200ミリ秒以内に動的に再配置される.
- 一時的な状態 (約. 300 ms) は,領域間センサーデータ伝送とコーディング冗長性のピークを示しました.
- 安定した,堅固な視覚的表現は0. 5秒ほどで発生し,細胞の反応の変動に耐えた.
- 感覚データに直角なグローバル変動モードで,刺激後の1秒間のタスク応答を伝達します.
結論:
- 神経皮質は,コードの冗長性と堅固なニューラル集団のコードを一時的に増やすことで感覚能力をサポートします.
- ダイナミックな領域間通信モードは,センサーデータとタスク応答の伝送を妨害することなく容易にします.
- 神経皮質の処理は 細胞の多様性に適応し 信頼性の高い感覚的差別を保証します
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