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Updated: Sep 22, 2025

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells
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ADAR1は,ZBP1誘発性ネクロプトーシスのがん免疫療法の希望を隠している

Ting Zhang1, Chaoran Yin1, Aleksandr Fedorov2

  • 1Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

Nature
|May 25, 2022
PubMed
まとめ

RNA編集酵素ADAR1は,ZRNAを抑制することで,抗がん免疫を阻害する. CBL0137でZBP1を活性化すると,ADAR1がバイパスされ,耐性がんの免疫反応が回復します.

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