局所的なバリアは,宿主と微生物群の間のシステム通信を構成する
Qiuhe Lu1, Thaddeus S Stappenbeck1
1Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Science (New York, N.Y.)
|May 26, 2022
まとめ
宿主の微生物群を理解することは 健康の鍵です 将来の治療用途のために重要な微生物とその化学信号を特定するために機能的研究が必要です.
科学分野:
- 微生物学
- 宿主 と 微生物 の 相互作用
- システム生物学
背景:
- 活気のある微生物のコミュニティである宿主の微生物群は 宿主の健康に不可欠です
- 微生物と宿主のコミュニケーションは 生理学的障壁を越えて分泌される分子を介して起こります
- オミックスの方法は,宿主プロセスと病気との多数の微生物の関連性を明らかにした.
研究 の 目的:
- 微生物群の研究における 翻訳のギャップを強調する
- 主要な微生物,菌株の変異,微生物代謝物に関する知識のギャップを特定する.
- 微生物群と宿主の相互作用を理解するための機能的アプローチの必要性を強調する.
主な方法:
- 既存の"オミックス"データと文献のレビュー.
- 機能的な微生物群の研究における課題の議論
- 国間相互作用 (バクテリア,ファージ,原生体,真菌) の探求
主要な成果:
- 進歩にもかかわらず,微生物群に基づく治療の翻訳的な成功は限られている.
- 特定の微生物の役割,菌株の重要性,代謝物質の機能に関する知識のギャップは大きい.
- 微生物同士の相互作用は 微生物群と宿主のダイナミクスを複雑にします
結論:
- 機能的研究は,微生物群の研究を進めるために不可欠です.
- 微生物群の化学的産物と 菌株レベルの変化を理解することは 極めて重要です
- 微生物群の治療的可能性を解き放つには 実験的な課題を克服する必要があります
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