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Updated: May 2, 2026

Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9
08:27

Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

Published on: April 10, 2018

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遺伝子編集されたヒトの造血性幹細胞の,化学療法による移植

Attya Omer-Javed1, Gabriele Pedrazzani2, Luisa Albano1

  • 1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.

Cell
|May 26, 2022
PubMed
まとめ

血液形成性幹細胞/原始細胞遺伝子療法 (HSPC-GT) は,動員された細胞をex vivoで救うことで移植を強化する. この戦略は遺伝疾患の治療のために 骨髄の再生を改善します

キーワード:
CRISPR-Casによる遺伝子編集RNAベースの配送X関連ハイパーIgM症候群オートログの幹細胞移植コンディショニングフリー遺伝子転送造血幹細胞人間の血液染色体マウスモデル動員する

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CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications08:32

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications

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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

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Stem Cell Therapy for Tissue Regeneration

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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