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Updated: Sep 21, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

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交流電流の周波数による選択的なアミン機能化のための1または2電子酸化制御

Disni Gunasekera1, Jyoti P Mahajan1, Yanick Wanzi1

  • 1Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.

Journal of the American Chemical Society
|May 27, 2022
PubMed
まとめ

研究者は,交流電流 (AC) 周波数を用いて選択的なアミン酸化のための新しい電気合成方法を開発しました. このアプローチは,アリレーション製品のための重要な中間物質を生成し,複雑な化学反応を簡素化し,最適な条件を予測します.

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Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
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