関連する実験動画

Updated: Sep 21, 2025

Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae
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Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae

Published on: January 10, 2018

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SARS-CoV-2核カプシドタンパク質の原子解像度構造 N-ターミナル領域

Sucharita Sarkar1,2, Brent Runge1,2, Ryan W Russell1,2

  • 1Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.

Journal of the American Chemical Society
|May 31, 2022
PubMed
まとめ

研究者は,NMRとX線微分法を使用して,SARS-CoV-2核カプシドのN末端領域 (NNTD) 構造を決定した. NNTDRNA結合部位に関するこの原子レベルの理解は,新しいCOVID-19治療法の開発に役立ちます.

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Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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