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Updated: Sep 21, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

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ランチペプチド生物合成における部分改変ペプチド中間物質は,ランチペプチド合成酵素の構造とダイナミクスを変化させる

Yeganeh Habibi1, Nuwani W Weerasinghe1, Kevin A Uggowitzer1

  • 1Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 0B8, Canada.

Journal of the American Chemical Society
|June 1, 2022
PubMed
まとめ

クラスIIランチペプチド合成酵素 (LanM酵素) は,前駆体ペプチドを複合的な天然製品に改造する. この研究では,前駆体ペプチドの改変が,ハルM2酵素の構造と動態を体系的に変化させ,高信頼性の生物合成を保証する方法を明らかにした.

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