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Updated: Sep 20, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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バックプロタックは,細菌における標的タンパク質の分解を媒介する

Francesca E Morreale1, Stefan Kleine2, Julia Leodolter1

  • 1Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria.

Cell
|June 6, 2022
PubMed
まとめ

研究者は細菌のタンパク質を分解する 細菌タンパク質を標的とするキメラ (BacPROTAC) を開発した. この新しい技術は,標的型タンパク質破壊のためのClpC:ClpPプロテアスを活性化させ,抗生物質の発見のための新しい道を開きます.

キーワード:
AAA プロテアゼ抗菌剤バクテリアによる PROTACs標的型タンパク質の分解

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